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  • Title: [Anchoring proteins and cardiac sudden death: how and why?].
    Author: Pourrier M, Nattel S.
    Journal: Med Sci (Paris); 2004 Apr; 20(4):437-41. PubMed ID: 15124116.
    Abstract:
    Mutations in proteins responsible for ion transport in cardiac tissue can induce a destabilization of electrical function and provoke cardiac sudden death. Identification of a genetic anomaly in a French family that developed the syndrome of cardiac sudden death has revealed a crucial new element in normal cardiac electrical function : Ion channels need to be anchored to specific domains at the plasma membrane by an anchoring protein called ankyrin-B.
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