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  • Title: Identification of purine inhibitors of phosphodiesterase 7 (PDE7).
    Author: Pitts WJ, Vaccaro W, Huynh T, Leftheris K, Roberge JY, Barbosa J, Guo J, Brown B, Watson A, Donaldson K, Starling GC, Kiener PA, Poss MA, Dodd JH, Barrish JC.
    Journal: Bioorg Med Chem Lett; 2004 Jun 07; 14(11):2955-8. PubMed ID: 15125967.
    Abstract:
    A series of purine based inhibitors of PDE7 has been derived from screening lead 1a. The synthesis, structure-activity relationships (SAR), and selectivity against several other PDE family members are described.
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