These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Synthesis of cytochrome c oxidase models bearing a Tyr244 mimic.
    Author: Collman JP, Decréau RA, Zhang C.
    Journal: J Org Chem; 2004 May 14; 69(10):3546-9. PubMed ID: 15132568.
    Abstract:
    A close structural analogue of the metal-free cytochrome c oxidase active site has been synthesized. This model has a proximal imidazole tail and three distal imidazole pickets attached to a porphyrin. One distal imidazole is cross-linked to a phenol, mimicking Tyr(244). The strategy behind the successful synthesis of this regioisomerically pure model involved discovering the best sequence to introduce the phenol-substituted imidazole and employing a fluorinated substituent.
    [Abstract] [Full Text] [Related] [New Search]