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  • Title: Fully automated polymer-assisted synthesis of 1,5-biaryl pyrazoles.
    Author: Vickerstaffe E, Warrington BH, Ladlow M, Ley SV.
    Journal: J Comb Chem; 2004; 6(3):332-9. PubMed ID: 15132592.
    Abstract:
    The polymer-assisted solution-phase (PASP) synthesis of a 192-member 2-D array of 1,5-biaryl pyrazoles 4[1-12,1-16] is reported. The synthesis was performed in a fully automated manner using a multiprobe top-filtration robot and incorporates a "catch and release" step to afford library compounds directly in high yield and purity.
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