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  • Title: SATE pronucleotide approaches: an overview.
    Author: Peyrottes S, Egron D, Lefebvre I, Gosselin G, Imbach JL, Périgaud C.
    Journal: Mini Rev Med Chem; 2004 May; 4(4):395-408. PubMed ID: 15134542.
    Abstract:
    This review depicts in vitro and in vivo results obtained with nucleotide prodrugs (pronucleotides) bearing S-acyl-2-thioethyl (SATE) groups as esterase-labile phosphate protections. New developments are illustrated by the design of mononucleoside mixed phosphoester derivatives leading to the selective intracellular delivery of the corresponding 5'-mononucleotide through two different enzyme-mediated activation steps.
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