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  • Title: The CD8 isoform CD8alphaalpha is not a functional homologue of the TCR co-receptor CD8alphabeta.
    Author: Gangadharan D, Cheroutre H.
    Journal: Curr Opin Immunol; 2004 Jun; 16(3):264-70. PubMed ID: 15134773.
    Abstract:
    Although structurally similar, CD8alphabeta and CD8alphaalpha have notably diverted with regard to function. Whereas CD8alphabeta functions as a T-cell receptor (TCR) co-receptor on MHC-class-I-restricted thymocytes and mature T cells, CD8alphaalpha is unable to support conventional positive selection, and can be expressed on T cells independent of the MHC restriction of their TCR. CD8alphaalpha induction is consistent with antigenic stimulation through the TCR, and recent developments have now shown that CD8alphaalpha induced on agonist-triggered immature thymocytes, antigenic-stimulated conventional CD8alphabeta T cells and mucosal T cells mediates the specific modulation of TCR activation signals to facilitate their survival and differentiation into various specialized T-cell subsets.
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