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  • Title: Emerging paradigms of T-cell co-stimulation.
    Author: Kroczek RA, Mages HW, Hutloff A.
    Journal: Curr Opin Immunol; 2004 Jun; 16(3):321-7. PubMed ID: 15134781.
    Abstract:
    The analysis of recent data reveals that T-cell co-stimulation is a hierarchical process with elements of mutual interdependence between individual co-stimulators. The expression and function of co-stimulatory molecules is biased on various T-cell subsets and is dependent on the T-cell differentiation state. The classical paradigm of T-cell co-stimulation by professional antigen-presenting cells has to incorporate the newly recognized concept of T-cell co-stimulation in the interaction with peripheral tissues, such as endothelial or epithelial cells. The two signal paradigm of T-cell co-stimulation is being replaced by a multisignal integration concept of central and peripheral co-stimulation.
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