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  • Title: Affinity adsorbent based on combinatorial phage display peptides that bind alpha-cobratoxin.
    Author: Byeon WH, Weisblum B.
    Journal: J Chromatogr B Analyt Technol Biomed Life Sci; 2004 Jun 15; 805(2):361-3. PubMed ID: 15135114.
    Abstract:
    Combinatorial phage display was used to discover peptides that selectively bind to the alpha-cobratoxin (neurotoxin) component of the multi-component venom of the Thai cobra, Naja kaouthia. Peptide sequences determined in this way were synthesized chemically and were covalently attached to agarose through the alpha-amino terminus. Such affinity chromatography supports selectively bound the alpha-cobratoxin component from crude venom, while passage of the crude venom over the support selectively depleted the venom of this component. The selective binding of alpha-cobratoxin to peptide-based solid-phase supports suggests that a limitless variety of peptides similarly obtained by combinatorial phage display can be used to craft specific analytical and preparative tools.
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