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  • Title: Preparation of synthetic glycoconjugates as potential vaccines against Shigella flexneri serotype 2a disease.
    Author: Wright K, Guerreiro C, Laurent I, Baleux F, Mulard LA.
    Journal: Org Biomol Chem; 2004 May 21; 2(10):1518-27. PubMed ID: 15136809.
    Abstract:
    The synthesis of three neoglycopeptides incorporating carbohydrate haptens, differing in length, covalently linked to a non natural universal T helper peptide is disclosed. They were synthesized according to a blockwise strategy based on the condensation of appropriate di-, tri-, and tetrasaccharide trichloroacetimidate donors onto an azidoethyl 2-acetamido-2-deoxybeta-D-glucopyranoside acceptor. Use of thiol-maleimide coupling chemistry allowed site-selective efficient conjugation.
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