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  • Title: Oxiracetam prevents haloperidol-induced passive avoidance impairment in mice.
    Author: Castellano C, Battaglia M, Sansone M.
    Journal: Pharmacol Biochem Behav; 1992 Aug; 42(4):797-801. PubMed ID: 1513861.
    Abstract:
    The nootropic drug oxiracetam (50 mg/kg) prevented passive avoidance impairment induced by posttraining administration of haloperidol (0.25 and 0.5 mg/kg). Conversely, oxiracetam did not antagonize either locomotor depression or suppression of active avoidance responses induced by the dopamine receptor blocking agent. The results indicate that prevention of haloperidol-induced retention impairment, by oxiracetam, may be due to a not yet defined protective action, common to other nootropic agents, on different types of experimental amnesias, rather than to a specific interaction with dopaminergic mechanisms.
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