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  • Title: Investigations into the antinociceptive activity of Sapindus trifoliatus in various pain models.
    Author: Arulmozhi DK, Veeranjaneyulu A, Bodhankar SL, Arora SK.
    Journal: J Pharm Pharmacol; 2004 May; 56(5):655-61. PubMed ID: 15142344.
    Abstract:
    The effect of the aqueous extract of Sapindus trifoliatus (ST) on chemical, thermal-induced pain, nitroglycerin-induced hyperalgesia and pain on inflamed tissue was investigated. The extract (20 and 100 mg x kg(-1), i.p.) significantly inhibited acetic-acid-induced abdominal constrictions, formalin-induced pain licking and hotplate-induced pain in mice. Furthermore, the extract significantly increased the response latencies of nitroglycerin-induced hyperalgesia by the tail-flick method and mechanical pain on carrageenan-induced inflamed paw in rats. The data suggest that ST has an inhibitory activity on both peripheral and central pain mechanisms and has a modulatory role in NO-mediated nociceptive transmission.
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