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  • Title: [Participation of monoaminergic mechanisms and the striatum in the development of "petit mal" induced by corazole].
    Author: Arushanian EB, Avakian RM.
    Journal: Zh Nevropatol Psikhiatr Im S S Korsakova; 1978; 78(8):1175-81. PubMed ID: 151468.
    Abstract:
    In gradual cumulation of subconvulsive doses of corasole in mice there are certain changes of behaviour and electrographical signs which are close to "petit mal": slow negative waves and peak-wave complexes on the EEG, myoclonic jerks. An increase of monoaminergic transmission of apomorphine, DOPA, or 5--hydroxyhyptophane weakens the preconvulsive effect of corasol, while its inhibition by aminasine, haloperidol and p-chlorphenylalanine on the contrary increases it. A low frequency electric stimulation of the striatum potentiates the expressiveness of corasole "petit mal", while its destruction limits it. A bilateral destruction of the striatum eliminates the action of apomorphine, DOPA and haloperidol but only slightly changes the effect of aminazine, 5-hydroxytryptophane and p-chlorphenylalanine.
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