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  • Title: Case of polymorphic ventricular tachycardia in diphenhydramine poisoning.
    Author: Joshi AK, Sljapic T, Borghei H, Kowey PR.
    Journal: J Cardiovasc Electrophysiol; 2004 May; 15(5):591-3. PubMed ID: 15149431.
    Abstract:
    This is the first reported case of torsades de pointes attributable to diphenhydramine, a drug with weak I(Kr) effects. A 26-year-old, healthy man was admitted to intensive care after a diphenhydramine overdose. Results of physical examination, ECG, and electrolytes were normal at admission. Despite supportive care, he developed typical, sustained, torsades de pointes with a markedly prolonged QT interval requiring cardioversion. Drugs with weak I(Kr)-blocking effects may cause lethal proarrhythmia in susceptible individuals when delivered in high concentrations. This case illustrates the variation in repolarization reserve that exists in a free-standing population.
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