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  • Title: The synthesis and antimicrobial evaluation of a new series of isoxazolinyl oxazolidinones.
    Author: Weidner-Wells MA, Werblood HM, Goldschmidt R, Bush K, Foleno BD, Hilliard JJ, Melton J, Wira E, Macielag MJ.
    Journal: Bioorg Med Chem Lett; 2004 Jun 21; 14(12):3069-72. PubMed ID: 15149646.
    Abstract:
    A series of oxazolidinone antibacterial agents containing a 5-substituted isoxazol-3-yl moiety were synthesized via a nitrile oxide [3+2] dipolar cycloaddition reaction. These compounds were screened against a panel of susceptible and resistant Gram-positive organisms. Several analogs from this series were comparable to or more potent than linezolid in vitro.
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