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  • Title: Structure-based design, synthesis, and antimicrobial activity of purine derived SAH/MTA nucleosidase inhibitors.
    Author: Tedder ME, Nie Z, Margosiak S, Chu S, Feher VA, Almassy R, Appelt K, Yager KM.
    Journal: Bioorg Med Chem Lett; 2004 Jun 21; 14(12):3165-8. PubMed ID: 15149667.
    Abstract:
    The structure-based design, synthesis, and biological activity of novel inhibitors of S-adenosyl homocysteine/methylthioadenosine (SAH/MTA) nucleosidase are described. Using 6-substituted purine and deaza purines as the core scaffolds, a systematic and structure guided series of modifications provided low nM inhibitors with broad-spectrum antimicrobial activity.
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