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  • Title: Thiol-based SAHA analogues as potent histone deacetylase inhibitors.
    Author: Suzuki T, Kouketsu A, Matsuura A, Kohara A, Ninomiya S, Kohda K, Miyata N.
    Journal: Bioorg Med Chem Lett; 2004 Jun 21; 14(12):3313-7. PubMed ID: 15149697.
    Abstract:
    In order to find novel nonhydroxamate histone deacetylase (HDAC) inhibitors, a series of thiol-based compounds modeled after suberoylanilide hydroxamic acid (SAHA) was synthesized, and their inhibitory effect on HDACs was evaluated. Compound 6, in which the hydroxamic acid of SAHA was replaced by a thiol, was found to be as potent as SAHA, and optimization of this series led to the identification of HDAC inhibitors more potent than SAHA.
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