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  • Title: A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics.
    Author: Takei Y, Kadomatsu K, Yuzawa Y, Matsuo S, Muramatsu T.
    Journal: Cancer Res; 2004 May 15; 64(10):3365-70. PubMed ID: 15150085.
    Abstract:
    Vascular endothelial growth factor (VEGF) plays a critical role during normal embryonic angiogenesis and also in the pathological angiogenesis that occurs in a number of diseases, including cancer. We developed a novel VEGF blockade system using RNA interference. The small interfering RNA (siRNA) targeting human VEGF almost completely inhibited the secretion of VEGF in a human prostate cancer cell line, PC-3, whereas the control scramble siRNA showed no effects. The VEGF siRNA with atelocollagen dramatically suppressed tumor angiogenesis and tumor growth in a PC-3 s.c. xenograft model. Atelocollagen provided a beneficial delivering means by which stabilization and efficient transfection of the siRNA injected into the tumors were achieved.
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