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  • Title: [The study on the expression of caspase-3 in experimental brain contusion in rats].
    Author: Tao LY, Chen XP, Bian SZ.
    Journal: Fa Yi Xue Za Zhi; 2004; 20(1):9-12. PubMed ID: 15150872.
    Abstract:
    OBJECTIVE: To investigate the expression of caspase-3 in different posttraumatic intervals and severity of brain injury. METHODS: The study examined brain tissue samples of slight (n = 24), severe (n = 24) brain injury and control (n = 6) of rat, using immunohistochemical staining, western-blot and RT-PCR method. RESULTS: Up-regulating of caspase-3 expression was found in tissue from traumatic brain injury compared with controls in early 1 hour after TBI, and lasted for 14 days. The gray degree and threshold area of caspase-3 positive cells is different in different severity of brain injury. CONCLUSION: The increasing of caspase-3 expression indicates that TBI exists. The gray degree, threshold area of caspase-3 positive cells and the cleavage degree of pro-caspase-3 have association with the severity of brain injury.
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