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  • Title: [Ultrasound microbubbles promote thrombolysis of rabbit femoral artery thrombus].
    Author: Ou WC, Xiu JC, Xie JG, Zha DG, Liu J, Hao R, Bin JP, Liu YL.
    Journal: Di Yi Jun Yi Da Xue Xue Bao; 2004 May; 24(5):536-8. PubMed ID: 15151826.
    Abstract:
    OBJECTIVE: To evaluate the efficacy of intravenous ultrasound microbubbles for thrombolysis of arterial thrombus without using thrombolytic drugs. METHODS: Twelve rabbit models of acute bilateral femoral artery thrombosis were established and 6 of them received transcutaneous ultrasound and intravenous albumin microbubble treatment for thrombosis on one side while only microbubble treatment for the other side. The other 6 rabbits received ultrasound treatment on one side but no treatment on the other to serve as the control group. RESULTS: None of the 6 arteries treated with microbubbles alone and only 2 arteries treated with ultrasound alone in the 6 control rabbits were recanalized. All the 6 femoral arteries treated with microbubbles together with ultrasound were recanalized (P=0.014), with significantly shorter patent time and smaller residual thrombus cross-sectional area than those of the arteries with only ultrasound treatment (P=0.004 and P=0.003, respectively). CONCLUSION: Treatment with intravenous microbubbles assisted by transcutaneous ultrasound effectively promotes arterial thrombolysis in vivo, and this technique can be of significance in clinical treatment of acute thrombotic occlusions.
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