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  • Title: [Intestinal permeability of patients with advanced digestive tract malignant tumors].
    Author: Yao YC, Chen CL, Wang JD, Zhang YL, Jiang B, Xiong DX.
    Journal: Di Yi Jun Yi Da Xue Xue Bao; 2004 May; 24(5):569-71. PubMed ID: 15151836.
    Abstract:
    OBJECTIVE: To assess the intestinal barrier function of patients with advanced digestive tract malignant tumors by measuring the changes in intestinal permeability. METHODS: Sixteen patients with digestive tract tumors and 16 healthy volunteers were enrolled. After oral administration of mannitol and lactulose in deionized water, the 6-hour urine samples were collected for analyzing mannitol and lactulose concentrations using gas-liquid chromatography. RESULTS: Urine lactulose concentration and lactulose/mannitol (L/M) ratio of the tumor patients were increased in comparison with those of the healthy subjects (P<0.05). CONCLUSION: he intestinal permeability increased in these tumor patients, indicating intestinal barrier dysfunction.
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