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  • Title: [Adverse reactions to medications in patients in ambulatory otorhinolaryngology].
    Author: Valladares J, Ferrer JM, Palop V, Rubio E, Morales Olivas FJ.
    Journal: Acta Otorrinolaringol Esp; 1992; 43(3):213-7. PubMed ID: 1515189.
    Abstract:
    A 12 months prospective study to detect adverse drug reactions (ADR) was carried out in an ORL outpatients clinic. 52 patients (1.8%) out of 2891 examined suffered one or more ADRs. The incidence was higher in women and in older patients. 94% of the ADRs were mild to moderate and 3 patients suffered irreversible lesions. Reactions were most commonly located in the nervous system (50%) and gastrointestinal tract (21%). The most common drugs involved were cardiovascular (40%) and central nervous system (25%) active drugs. Papers concerning ADRs published from 1976 to 1985 in spanish otorhinolaringologic journals have also been analyzed. 0.88% of 1357 published papers described ADRs. The incidence of ADRs observed in our study is higher than expected from the low number of papers published on this subject.
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