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  • Title: [Mechanism of biosynthesis of glycoconjugates at the level of the arterial walls after contact with alloplastic materials (author's transl)].
    Author: Guidollet J, Chignier E, Devolfe C, Serres-Guiliaumond M, Descotes J, Louisot P.
    Journal: Ann Biol Clin (Paris); 1978; 36(2):63-7. PubMed ID: 151521.
    Abstract:
    The object of this work was to show that here exists after contact with foreign substances, a construction of protein, glycoprotein and mucopolysaccharide macromolecules at the level of the intima of the great vessels. Woven Dacron prostheses have been implanted in the arterial circulation of dogs (on the subrenal abdominal aorta). After removal of vascular segments, we carried out a subcellular fractioning, controlled and studied in an acellular system in vitro the activity of the glycosyltransferases implied in the construction of glycan chains of glyccproteins. The results are discussed in relation to the duration of implantation of the prosthesis. The modifications observed differ according to the position of the sugars in the glycan chains, in particular as far as sialic acid is concerned, and lead to an interpretation of the mechanism of endovascular reactions when faced with foreign material.
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