These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Immunohistochemical study of the prostate-specific antigen in prostatic cancer].
    Author: Karseladze AI, Rytin IIe, Budunova IV.
    Journal: Arkh Patol; 2004; 66(2):3-7. PubMed ID: 15154373.
    Abstract:
    Prostate-specific antigen (PSA) is secreted both by normal epithelial prostatic cells and cell of prostatic carcinoma (PC). No parallelism exists between the degree of PC differentiation and the type of PSA secretion. PSA concentration in the peripheral blood not always corresponds to the intensity of its immunoreactivity on the tissue level. Amount of PSA in the blood depends on the stroma vascularisation and number of cells contacting with the organ stroma. A decrease of PSA in the peripheral blood due to therapy may be combined with high intensity of its synthesis in tumor cells. PSA immunohistochemistry may be recommended as a method of PC clinical course monitoring and dynamics of its changes in the course of carcinoma therapy.
    [Abstract] [Full Text] [Related] [New Search]