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  • Title: [Embryonic mechanisms in development of spina bifida in humans].
    Author: Vostrikov OV, Zotov VA, Nikitenko EV.
    Journal: Arkh Patol; 2004; 66(2):21-5. PubMed ID: 15154378.
    Abstract:
    The study of 86 human embryos and fetuses beginning from 23rdday of development up to 18th week after fecundation has detected 23 cases of pathologic development which correspond to the modern definition of spina bifida (SB). It is shown that the cause of various forms of the anomaly is the disturbance or temporary delay of a movement of caudal neurulation wave forming the spinal cord. The anomaly size and type are determined by the time and duration of a pathogenic action on neurulation. Postnatal or the 1st type of SB develops in neurulation wave disturbance not longer than 4-6 hours. Anomaly consequence may be compensated surgically. The 2nd or fetal type of SB arises when neurulation delay is from 6 to 20 hours. If the delay occurs on the 22-24th day of development, embryos die by the neurulation end. If the delay takes place on the 26-28th day embryos may survive till the late fetal period. In embryonal or type III of SB embryos die by the end of the 8th week and do not enter the medical statistics. Their death is associated with delayed movement of the caudal neurulation wave for 24 hours and longer. This results in a spontaneous abortion.
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