These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Meta-analysis of 2-treatment clinical trials including both continuous and dichotomous results.
    Author: Babbs CF.
    Journal: Med Decis Making; 2004; 24(3):299-312. PubMed ID: 15155019.
    Abstract:
    To expedite the timely creation of medical practice guidelines, a meta-analytic method was developed to combine both dichotomous survival data and continuous physiologic data from multiple studies of differing experimental design, which compare the same innovative clinical intervention to standard care. An aggregate ratio, R*, of the observed treatment effect to a clinically optimal treatment effect for studies in a series is computed and compared to the 95% confidence limit for R* under the null hypothesis. Input data for continuous variables include sample means, standard errors, and sample sizes. Input data for dichotomous variables include group proportions and sizes. The analysis can be done using a simple, 1-page spreadsheet. It allows one to judge biological significance, to test for statistical significance, to compare subgroups of studies, to test for outliers, and to compute the power of the meta-analysis. These features are demonstrated for studies of interposed abdominal compression-cardiopulmonary resuscitation.
    [Abstract] [Full Text] [Related] [New Search]