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  • Title: Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain.
    Author: Lingel A, Simon B, Izaurralde E, Sattler M.
    Journal: Nat Struct Mol Biol; 2004 Jun; 11(6):576-7. PubMed ID: 15156196.
    Abstract:
    We describe the solution structures of the Argonaute2 PAZ domain bound to RNA and DNA oligonucleotides. The structures reveal a unique mode of single-stranded nucleic acid binding in which the two 3'-terminal nucleotides are buried in a hydrophobic cleft. We propose that the PAZ domain contributes to the specific recognition of siRNAs by providing a binding pocket for their characteristic two-nucleotide 3' overhangs.
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