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  • Title: PrPSc accumulation in myocytes from sheep incubating natural scrapie.
    Author: Andréoletti O, Simon S, Lacroux C, Morel N, Tabouret G, Chabert A, Lugan S, Corbière F, Ferré P, Foucras G, Laude H, Eychenne F, Grassi J, Schelcher F.
    Journal: Nat Med; 2004 Jun; 10(6):591-3. PubMed ID: 15156203.
    Abstract:
    Because variant Creutzfeldt-Jakob disease (vCJD) in humans probably results from consumption of products contaminated with tissue from animals with bovine spongiform encephalopathy, whether infectious prion protein is present in ruminant muscles is a crucial question. Here we show that experimentally and naturally scrapie-affected sheep accumulate the prion protein PrP(Sc) in a myocyte subset. In naturally infected sheep, PrP(Sc) is detectable in muscle several months before clinical disease onset. The relative amounts of PrP(Sc) suggest a 5,000-fold lower infectivity for muscle as compared to brain.
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