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  • Title: Scopoletin suppresses pro-inflammatory cytokines and PGE2 from LPS-stimulated cell line, RAW 264.7 cells.
    Author: Kim HJ, Jang SI, Kim YJ, Chung HT, Yun YG, Kang TH, Jeong OS, Kim YC.
    Journal: Fitoterapia; 2004 Jun; 75(3-4):261-6. PubMed ID: 15158982.
    Abstract:
    Scopoletin (1-50 microg/ml) inhibited the release of PGE2, TNF-alpha, IL-1beta and IL-6 and suppressed the expression of COX-2 in a concentration-dependent manner. These results suggest that scopoletin might suppress the production of such pro-inflammatory cytokines and exert inhibitory activity on LPS-induced PGE2 production through the depression of COX-2 expression.
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