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  • Title: The in vitro antibacterial/synergistic activities of Withania somnifera extracts.
    Author: Arora S, Dhillon S, Rani G, Nagpal A.
    Journal: Fitoterapia; 2004 Jun; 75(3-4):385-8. PubMed ID: 15159002.
    Abstract:
    The methanol, hexane and diethyl ether extracts from both leaves and roots of Withania somnifera were evaluated for the antibacterial/synergistic activity by agar plate disc-diffusion assay against Salmonella typhimurium and Escherichia coli. Different concentrations of Tibrim, a combination of rifampicin and isoniazid, were tested to find out the minimum inhibitory concentration (MIC), which came out to be 0.1 mg/ml for S. typhimurium and E. coli. From the six extracts tested, only methanol and hexane extracts of both leaves and roots were found to have potent antibacterial activity. A synergistic increase in the antibacterial effect of Tibrim was noticed when MIC of Tibrim was supplemented with these extracts.
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