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  • Title: Catalytic asymmetric synthesis of alpha-amino phosphonates using enantioselective carbon-carbon bond-forming reactions.
    Author: Kobayashi S, Kiyohara H, Nakamura Y, Matsubara R.
    Journal: J Am Chem Soc; 2004 Jun 02; 126(21):6558-9. PubMed ID: 15161276.
    Abstract:
    We have developed highly enantioselelctive reactions of silicon enolates with N-acyl-alpha-iminophosphonates leading to optically active alpha-amino phophonates. A copper (II)-diamine complex was shown to be effective in this reaction, and high levels of yield and selectivity were achieved. It is noteworthy that this reaction opens a way to various biologically important, optically active alpha-amino phosphonate derivatives.
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