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  • Title: (P)-helicene displays chiral selection in binding to Z-DNA.
    Author: Xu Y, Zhang YX, Sugiyama H, Umano T, Osuga H, Tanaka K.
    Journal: J Am Chem Soc; 2004 Jun 02; 126(21):6566-7. PubMed ID: 15161280.
    Abstract:
    Enantiomeric helicenes of (P)-A and (M)-A were synthesized. The binding of the helicenes to B- and Z-DNA was studied quantitatively by CD, equilibrium dialysis, and fluorescence spectroscopy. Enantiomeric (P)-A not only bound selectively to Z-DNA but also effectively converted the B-DNA conformation to Z-DNA. The enantioselectivity of the helicenes offers a new route for the rational design of inhibitors of biological functions that may depend on Z-DNA.
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