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  • Title: Comparative effects of quinapril with enalapril in rats with heart failure.
    Author: Watanabe K, Ma M, Wen J, Tachikawa H, Kodama M, Aizawa Y, Yamaguchi K, Takahashi T.
    Journal: Pharmacology; 2004 Jul; 71(3):157-61. PubMed ID: 15161998.
    Abstract:
    The cardioprotective properties of angiotensin-converting enzyme (ACE) inhibitors, quinapril and enalapril were studied in a rat model of heart failure. Seventy-five rats were divided into five groups and administered quinapril or enalapril at 2 and 20 mg/kg/day (groups Q2, Q20, E2 and E20) or vehicle alone (group V, all groups n = 15). Although both ACE inhibitors improved survival rate and ventricular function in a dose-dependent manner, the left ventricular end-diastolic pressure and expression level of transforming growth factor-beta1 mRNA were the lowest in group Q20. These results suggest that quinapril may confer greater protection than enalapril against injury from the renin-angiotensin system in heart failure.
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