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  • Title: Synthesis and antibacterial activity of a novel class of 4'-substituted 16-membered ring macrolides derived from tylosin.
    Author: Phan LT, Jian T, Chen Z, Qiu YL, Wang Z, Beach T, Polemeropoulos A, Or YS.
    Journal: J Med Chem; 2004 Jun 03; 47(12):2965-8. PubMed ID: 15163176.
    Abstract:
    Novel 4'-substituted 16-membered ring macrolides were synthesized by the cleavage of the mycarose sugar of tylosin and subsequent modification of 4'-hydroxyl group. This new class of macrolide antibiotics exhibited potent activity against some key erythromycin-resistant pathogens.
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