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  • Title: [Screening of TNF-alpha mimotopes from c7c phage display peptide library].
    Author: Luo HB, Liu BY, Liu YJ, Zhu P, Fu N.
    Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi; 2003 Jul; 19(4):322-5. PubMed ID: 15163373.
    Abstract:
    AIM: To acquire oligo-peptides mimicking TNF-alpha epitopes. METHODS: The TNF-alpha mimotopes were screened from c7c phage display peptide library by using neutralizing mAb J1D9 against TNF-alpha, and positive clones were identified by sandwich ELISA. RESULTS: 9 out of 20 phage clones were identified as positive clones which can bind to mAb J1D9. The deduced amino acid sequence analysis showed three different sequences: c-RRPAQSG-c, c-NKHNRKI-c and c-RGMSRKI-c. CONCLUSION: All of the three peptides obtained can mimic the epitopes of TNF-alpha and bind to mAb J1D9.
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