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  • Title: Further bioactive piperidine alkaloids from the flowers and green fruits of Cassia spectabilis.
    Author: Viegas C, da S Bolzani V, Furlan M, Barreiro EJ, Young MC, Tomazela D, Eberlin MN.
    Journal: J Nat Prod; 2004 May; 67(5):908-10. PubMed ID: 15165164.
    Abstract:
    The flowers of Cassia spectabilis yielded three new piperidine alkaloids, (-)-3-O-acetylspectaline (1), (-)-7-hydroxyspectaline (2), and iso-6-spectaline (3), together with the known (-)-spectaline (4). The green fruits of this plant were also investigated, resulting in the isolation of 1 and 4. Their structures were elucidated using a combination of multidimensional NMR and MS techniques, and relative stereochemistries were established by NOESY correlations and analysis of coupling constants. The DNA-damaging activity of these compounds was evaluated using a mutant yeast, Saccharomyces cerevisiae, assay.
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