These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Study on the enantiomer separation of cetirizine dihydrochloride using proteinate- and amylose-based chiral stationary phase].
    Author: Zhang ZF, Yang GL, Liang GJ, Zhou Y, Chen Y.
    Journal: Yao Xue Xue Bao; 2004 Mar; 39(3):204-7. PubMed ID: 15171656.
    Abstract:
    AIM: To study the chromatographic behavior of cetirizine dihydrochloride on the proteinate- and amylose- based chiral stationary phases so as to optimizate the chromatographic condition of its enantiomers separation. METHODS: When using amylose-based, alpha1-acid glycoprotein and ovomucoid protein chiral stationary phase, the mobile phase was hexane-isopropyl alcohol-alcohol-trifluoroacetic acid (430:45:25:1), acetonitrile-10 mmol x L(-1) phosphate buffer solution (adjusted to pH 7.0 with sodium hydroxide) (4:96) and acetonitrile-20 mmol x L(-1) KH, PO4 solution (adjusted to pH 7.0 with triethylamine) (12.7:87.3), respectively. The temperature of proteinate column was 25 degrees C. The detective wavelength was 230 nm. RESULTS: The two enantiomers could be separated on the two kinds of chiral stationary phases without derivatization and the resolution was above 2.0. The methods developed on the two kinds of chiral stationary phases are accurate, sensitive and specific. CONCLUSION: Both the proteinate- and amylose-based chiral stationary phases can be used to separate the enantiomers of cetirizine.
    [Abstract] [Full Text] [Related] [New Search]