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  • Title: Lack of association of interleukin-1beta polymorphism with Alzheimer's disease in the Jewish population.
    Author: Rosenmann H, Meiner Z, Dresner-Pollak R, Kahana E, Aladjem Z, Grenader T, Wertman E, Abramsky O.
    Journal: Neurosci Lett; 2004 Jun 10; 363(2):131-3. PubMed ID: 15172100.
    Abstract:
    A growing body of evidence suggests that Alzheimer's disease (AD) is associated with local inflammation processes, including the activation of inflammatory cytokines. We performed a case-control association study between sporadic AD patients and the exon 5 position +3953 polymorphism in the potent pro-inflammatory cytokine, interleukin-1beta (IL-1B). Recent association studies of this locus with AD revealed conflicting results, suggesting that the association - if it exists - is not universal but rather population specific. In our study no association was detected with AD: neither as a risk factor nor as a modifier gene affecting the age at onset and disease progression. These findings show no evidence for an association between the IL-1B +3953 polymorphism and AD in the Jewish population.
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