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  • Title: Stereoselective ketal-tethered intramolecular diels-alder cycloadditions. An approach to the 2-oxadecalin spiroketal core of antifungal agent fusidilactone C.
    Author: Wang J, Hsung RP, Ghosh SK.
    Journal: Org Lett; 2004 Jun 10; 6(12):1939-42. PubMed ID: 15176788.
    Abstract:
    [reaction: see text] An approach toward the 2-oxadecalin spiroketal core of fusidilactone C via a rare ketal-tethered intramolecular Diels-Alder cycloaddition is described here. This intramolecular Diels-Alder cycloaddition is highly endo-selective and overall depended upon the nature of solvents and Lewis acids. We also observed some remarkable rate acceleration in MeOH.
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