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  • Title: Synthesis of new 2'-beta-C-methyl related triciribine analogues as anti-HCV agents.
    Author: Smith KL, Lai VC, Prigaro BJ, Ding Y, Gunic E, Girardet JL, Zhong W, Hong Z, Lang S, An H.
    Journal: Bioorg Med Chem Lett; 2004 Jul 05; 14(13):3517-20. PubMed ID: 15177464.
    Abstract:
    Ten new beta-D-ribofuranosyl and 2'-beta-C-methyl-beta-D-ribofuranosyl triciribine derivatives 4-13 with various N4 and 6-N substituents on the tricyclic ring were synthesized from the corresponding toyocamycin and new 2'-beta-C-methyl toyocamycin derivatives. The inhibitory studies of these compounds in the HCV replicon assay reveal that some of them possess interesting anti-HCV properties with low cytotoxicity.
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