These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Axonal damage in multiple sclerosis: a complex issue in a complex disease.
    Author: Grigoriadis N, Ben-Hur T, Karussis D, Milonas I.
    Journal: Clin Neurol Neurosurg; 2004 Jun; 106(3):211-7. PubMed ID: 15177770.
    Abstract:
    Multiple sclerosis is no longer considered to simply be an autoimmune demyelinating disease. Axonal destruction is another central pathological feature and a contributor to the accumulating disability of disease progression. The mechanism underlying axonal pathology has not been fully clarified but does not appear to be a simple one. The relationship between axonal damage and other components of the pathological features such as demyelination, inflammation and remyelination are under intense investigation. Experimental data suggest that therapeutic interventions such as the induction of rapid remyelination may lead to the protection of axons. In addition to immunomodulation, future strategies for neuroprotection may be of great importance.
    [Abstract] [Full Text] [Related] [New Search]