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  • Title: Effect of long-term calcitonin therapy by injection and nasal spray on the incidence of fractures in osteogenesis imperfecta.
    Author: Nishi Y, Hamamoto K, Kajiyama M, Ono H, Kihara M, Jinno K.
    Journal: J Pediatr; 1992 Sep; 121(3):477-80. PubMed ID: 1517930.
    Abstract:
    The effect of calcitonin therapy by injection or nasal spray on the incidence of bone fractures was studied in patients with osteogenesis imperfecta. In contrast to injection of calcitonin, intranasal administration of calcitonin twice a week for 2 weeks, followed by 2 weeks of no therapy, was simple and seemed beneficial for decreasing bone fractures in patients with osteogenesis imperfecta.
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