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  • Title: [Activity of the messenger systems in the altitude chamber hypoxia].
    Author: Vishnevskiĭ AA, Iakovlev VM, Khabibullova ZI.
    Journal: Biomed Khim; 2004; 50(2):187-91. PubMed ID: 15179826.
    Abstract:
    The activity of phosphoinositide and adenylate cyclase systems of second messengers in rat brain were investigated under altitude chamber treatment (6000 m x 24 hours). Selective suppression of each messenger system was achieved by pretreatment of rats with either lithium chloride or propranolol for 8 days. Consequences of this treatment and/or hypoxia were evaluated by orientation behavior and physical exercise test. Administration of LiCl caused reduction of phosphoinositide level; hypoxia (6000 m) caused further impairments in the second messenger content. The synergism between phosphoinositide and adenylatcyclase systems was demonstrated.
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