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  • Title: [Clinical studies of panipenem/betamipron in pediatrics].
    Author: Morita H, Hamada F, Fujieda M, Hosokawa T, Maeda A, Maeda H, Hashizume M, Kido S, Hisakawa H, Kawakubo K.
    Journal: Jpn J Antibiot; 1992 Apr; 45(4):437-42. PubMed ID: 1518127.
    Abstract:
    We conducted clinical studies on panipenem/betamipron (PAPM/BP), a newly developed parenteral carbapenem antibiotic, for its clinical application in the field of pediatrics. 1. A clinical study was performed on 13 children with infections, including 6 with acute bronchopneumonia, 1 each with acute pharyngitis, acute bronchitis, sepsis, staphylococcal scalded skin syndrome, urinary tract infection, subcutaneous abscess and furuncle. PAPM/BP was administered by intravenous drip infusion. Doses varied from 12 to 27 mg/kg body weight were given t.i.d. or q.i.d. Lengths of treatment ranged from 4 to 25 days. Clinical efficacies were excellent in 3 and good in 9 cases, with an efficacy rate of 92%. 2. No adverse reactions were observed. In laboratory tests, elevations of GOT, GPT and urobilinogen were observed in 3 cases. It was concluded that PAPM/BP was a promising drug for the treatment of bacterial infections in children.
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