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  • Title: [Correlation between activation-induced cytidine deaminase gene polymorphism and atopic asthma and plasma IgE in adult].
    Author: Cui TP, Wang L, Jiang WC, Hu LH, Wu JM.
    Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi; 2003 Nov; 19(6):552-3. PubMed ID: 15182647.
    Abstract:
    AIM: To explore whether the activation-induced cytidine deaminase(AICDA) gene 8408 C/T polymorphism is related to adult atopic asthma and the level of plasma IgE. METHODS: The polymorphism of AICDA gene was detected by PCR and restriction fragment length polymorphism (PCR-RFLP). RESULTS: The frequencies of 8408T/T genotype had significant difference (P<0.05) between adult asthma patients and control group, while the frequencies of T allele between two groups were not significantly different. The total plasma IgE level in adult atopic asthma patients with 8408T/T genotype was higher than that in the patients with C/C and C/T genotypes(P<0.05). CONCLUSION: The 8408 T/T genotype of AICDA is correlated with atopic asthma and total plasma IgE level in adult.
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