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  • Title: [Significance of detecting urinary monocyte chemotactic peptide-1 in renal transplant recipient].
    Author: Sun XH, Tan JM, Wu WZ, Lin WH, Li QS, Fang YH.
    Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi; 2003 Nov; 19(6):563-4. PubMed ID: 15182651.
    Abstract:
    AIM: To detect the content of monocyte chemotactic peptide-1(MCP-1) and to investigate the role of MCP-1 in acute renal graft rejection. METHODS: Urinary MCP-1 level was detected by avidin biotin complex(ABC)ELISA. RESULTS: Urinary MCP-1 levels in renal function stable renal transplantation of recipients and control group were (416+/-21) microg/L and (408+/-11) microg/L, respectively. Urinary MCP-1 level in renal transplantation recipients with acute rejection was (1195+/-58) microg/L, which was notably higher than that in control group and renal function stable recipients (P<0.01). After anti-rejection treatment, urinary MCP-1 level decreased markedly in patients who responded to treatment. CONCLUSION: The urinary MCP-1 level is correlated closely with acute renal graft rejection and its increase may indicate ongoing acute renal rejection. Detection of urinary MCP-1 level may contribute to early diagnosis and prognostic judgement of acute graft rejection.
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