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  • Title: Developments in peptide and amide synthesis.
    Author: Albericio F.
    Journal: Curr Opin Chem Biol; 2004 Jun; 8(3):211-21. PubMed ID: 15183318.
    Abstract:
    The solid-phase methodology is key for an effective synthesis of peptides, from a milligram scale for research to a multi-kilo scale for drug production. Indeed, small peptides containing up to 20-30 amino acids are most readily synthesized by a solid-phase strategy. Larger peptides (up to 60 amino acids) should be synthesized by a convergent approach (i.e. synthesis of protected constituent peptides in solid-phase and combination of these units in solution). Larger peptides and proteins are prepared by chemical ligation, where unprotected segments have been prepared in solid-phase.
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