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  • Title: Complex phenotypic assays in high-throughput screening.
    Author: Clemons PA.
    Journal: Curr Opin Chem Biol; 2004 Jun; 8(3):334-8. PubMed ID: 15183333.
    Abstract:
    High-throughput screening (HTS), systematically testing thousands of small molecules to find candidates for lead optimization, primarily involves exposure of purified proteins to arrayed collections of small molecules. More complex phenotypic assays, such as cell-based or whole-organism assays, traditionally have flanked HTS, preceding it to validate new therapeutic targets, and following it to characterize new lead compounds in cellular contexts. Recently, however, cell- and organism-based phenotypic assays have increasingly been adopted as a primary screening platform for annotating small molecules.
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