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  • Title: Bull's-eye maculopathy secondary to herbal toxicity from uva ursi.
    Author: Wang L, Del Priore LV.
    Journal: Am J Ophthalmol; 2004 Jun; 137(6):1135-7. PubMed ID: 15183807.
    Abstract:
    PURPOSE: To report a case of bilateral bull's-eye maculopathy in a patient who ingested uva ursi, a known inhibitor of melanin synthesis, for 3 years before the onset of symptoms. DESIGN: Observational case report. METHODS: Both eyes of a female patient were examined in the clinical practice setting. RESULTS: A 56-year-old woman who ingested uva ursi for 3 years noted a decrease in visual acuity within the past year. Ocular examination including fluorescein angiography revealed a typical bull's-eye maculopathy bilaterally. CONCLUSIONS: Uva ursi is a known inhibitor of melanin synthesis. It is necessary to broaden the list of potential retinal toxic drugs to include herbal adjuvants such as Uva Ursi and to elicit a history of their use in patients with unexplained ocular findings.
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