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  • Title: Study of the green tea polyphenols catechin-3-gallate (CG) and epicatechin-3-gallate (ECG) as proteasome inhibitors.
    Author: Wan SB, Chen D, Dou QP, Chan TH.
    Journal: Bioorg Med Chem; 2004 Jul 01; 12(13):3521-7. PubMed ID: 15186836.
    Abstract:
    The green tea polyphenol catechin-3-gallate (CG) and epicatechin-3-gallate (ECG) were synthesized enantioselectively via a Sharpless hydroxylation reaction followed by a diastereoselective cyclization. Their potencies to inhibit the proteasome activity were measured. The unnatural enantiomers were found to be equally potent to the natural compounds.
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