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  • Title: [Delayed response of the red blood system (erythron) to carboplatin administration during pregnancy].
    Author: Karpova GV, Borovskaia TG, Timina EA, Pakhomova AV.
    Journal: Eksp Klin Farmakol; 2004; 67(2):38-40. PubMed ID: 15188759.
    Abstract:
    Pregnant rats exhibited regenerative anemia development 3 months upon a single intravenous injection of carboplatin in a maximum tolerated dose; the effect increased by the end of pregnancy. The character of changes in parameters of the peripheral and central erythron parts (increased level of erythrocyte hemolysis, decrease in the amount of erythrocytes, increase in the number of reticulocytes, development of erythropoietic hyperplasia in bone marrow and spleen) was indicative of the hemolytic type of anemia.
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